Home » Newswire » Indigenous American Ancestry May Be Associated With HER2-positive Breast Cancer – Technology Networks
Indigenous American Ancestry May Be Associated With HER2-positive Breast Cancer – Technology Networks
by ahnationtalk onApril 3, 2020104 Views
Apr 03, 2020
An increased proportion of Indigenous American (IA) ancestry was associated with a greater incidence of HER2-positive breast cancer, according to a study published in Cancer Research, a journal of the American Association for Cancer Research.
“The risk of breast cancer-related mortality varies between different populations, with Latina women having a greater risk of breast cancer-specific mortality than non-Hispanic white women,” said Laura Fejerman, PhD, associate professor of medicine at the University of California San Francisco. “Latina women tend to be diagnosed with more aggressive breast cancer subtypes, which may contribute to their greater risk of mortality, among other factors,” Fejerman added.
Breast cancers are classified into subtypes based on the status of hormone receptors and the human epidermal growth factor receptor 2 (HER2). These receptors respond to factors outside the cell and promote cellular proliferation. Breast cancers that have higher than normal levels of HER2 are referred to as HER2-positive breast cancers and tend to grow more aggressively than some other subtypes. HER2-positive breast cancers are more common in Latina women than in non-Hispanic white women, but the underlying reasons for this remain unclear.