The Canadian Partnership for Tomorrow Project (CPTP) is Canada’s largest population cohort that allows researchers to explore how genetics, environment, lifestyle, and behaviour interact and contribute to the development of cancer and other chronic diseases. The national cohort brings together six regional cohorts: BC Generations Project, Alberta’s Tomorrow Project, the Manitoba Tomorrow Project, Ontario Health Study, CARTaGENE, and the Atlantic Partnership for Tomorrow’s Health. These cohorts have cumulatively enrolled more than 320,000 Canadians who are older than 30. Baseline data has been harmonized across the country, creating a pan-Canadian resource of more than 1,600 measures of participant health and lifestyle factors, including, but not limited to: personal and family disease histories, medication use, sex and reproductive health, diet and nutrition, sun exposure, and alcohol and tobacco use. More than 150,000 participants have provided biological samples, measures of glycated hemoglobin, complete blood counts, and physical measurements (e.g., anthropometrics, blood pressure, and body fat percentage). A significant benefit of CPTP is that all participants have provided consent to link their information to regional administrative health databases. This unique feature enables the longitudinal analyses of changes in clinical outcomes carried out in parallel with the analysis of biologics and deeply characterized health and lifestyle information. Alongside a wealth of cardiometabolic phenotypes, CPTP is well positioned to support studies focused on how genetics and the environment interact to drive cancer, cardiovascular disease, diabetes onset, and other outcomes in the Canadian context.
Dr. Philip Awadalla, PhD, National Scientific Director for the CPTP, Director of Computational Biology, and the Executive Scientific Director of the Ontario Health Study at the Ontario Institute for Cancer Research, and Professor of Population and Medical Genomics at the University of Toronto.